HCSS HeavyBid uses Markup for the most part for the basis of establishing a bid price however there are times where a desired Profit is set as the goal to establish revenue. Markup is a percentage of cost while Profit is a percentage of sales. There is a direct relationship between the two.  I made up a spreadsheet where you can calculate one if you know the other.  Link is below.
Markup and Profit Spreadsheet

If there confusion on the difference the following is a Wikipedia article that addresses the subject in great detail.
Article 

If you want to use just a % Profit as opposed the markup on cost consider doing an addon and use “Job Value”. But be aware it profit calculated will be on the Balanced Bid and not the actual bid price.